147 SKELETAL GROWTH IN HYPERGLYCEMIC FETAL RATS
نویسندگان
چکیده
منابع مشابه
Hyperglycemic Conscious Rats
To test the hypothesis that increased flux through the hexosamine biosynthetic pathway can induce insulin resistance in skeletal muscle in vivo, we monitored glucose uptake, glycolysis, and glycogen synthesis during insulin clamp studies in 6-h fasted conscious rats in the presence of a sustained (7-h) increase in glucosamine (GlcN) availability. Euglycemic (7 mM) insulin (2,500 pM) clamps with...
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The interfibrillar spaces of skeletal muscle fibers in adult vertebrates contain two distinct membranous systems, the T system and the sarcoplasmic reticulum. Most of the T system is oriented transversely between the fibrils. Occasionally, longitudinal connections between the transversely oriented T system are seen (14). The sarcoplasmic reticulum is, in general, oriented longitudinally between...
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The early-life environment, particularly in the fetus, is now recognised as an important determinant of several adult-onset diseases. Thus, increased frequencies of hypertension, obesity, dyslipidemia and type 2 diabetes, collectively referred to as the ‘Metabolic Syndrome’, have been linked to intrauterine growth retardation (IUGR), an assumed marker of a poor fetal environment. These links ar...
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ABSTRACT Evaluation of intrauterine growth and determination of at risk neonates was done by weight criteria for each pregnancy age. This criteria in different populations is not similar. Main objective of this study was determination of intrauterine growth pattern in this region. Weights of 2380 term neonates and 788 preterm neonates that had a definite LMP and were born at Alzahra hospital i...
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The insulin-like growth factors (IGF)-I and -II have a predominant role in fetal growth and development. IGFs are involved in the proliferation, differentiation and apoptosis of fetal cells in vitro and the IGF serum concentration has been shown to be closely correlated with fetal growth and length. IGF transcripts and peptides have been detected in almost every fetal tissue from as early in de...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198506000-00167